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A short week was not friendly to the San Francisco 49ers as the team will be without key offensive pieces, including quarterback brock Purdy, against Los Angeles Rams on “Thursday night football.”
The broad recipients Ricky Pearsall and Jauan Jennings will also be inaccessible to the 49s on Thursday night.
Purdy missed Weeks 2 and 3 after suffering a toe injury in the season opener, but returned in week 4 against Jacksonville Jaguars. During the loss 26-21, Purdy’s toe injury flared up again.
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San Francisco 49ers Quarterback Brock Purdy (13) rolls out to pass against Chicago Bears during the first half of an NFL football match in Santa Clara, California, Sunday 8th December 2024. (Eakin Howard/AP Photo)
In return, Mac Jones will start its third start of the season.
He filled in to Purdy in the previous games and completed 66% of his passes in 563 yards with four touchdowns and an interception during this span. The 49s won both of these games.
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Jones also deals with a knee injury, but the 49s said he was a full practice participant on all three of their injury reports this week. He has no game status on his way into Thursday night.
Jennings is fighting against ankle and ribs, while Pearsall has been limited by a knee problem. The 49s will turn to recipients Kendrick Bourne and DeMarcus Robinson, the latter of whom debuted last week after serving a suspension.
San Francisco will also be without recipient Jordan Watkins (calf) and the defensive end Robert Beal (ankle), while the defensive tackle CJ West (thumb) is questionable.

San Francisco 49ers Quarterback Brock Purdy (13) throws a care against Los Angeles Rams in the second quarter at Levis Stadium on December 12, 2024. (CARY EDMONDSON-PREPARED PICTURES)
This is already a key game in the NFC West Race, with both teams going into 3-1 in the first of two matchups this season. Rams jumped back last week with a win after a crushing loss to Philadelphia Eagles as two blocked field targets sealed the defeat.
Matthew Stafford and Rams’ violation have thrive as the addition of Davante Adams to play with Puka Nacua and Kyren Williams has led to the fourth most yards per year. Fight in the league this season.

Brock Purdy from San Francisco 49ers looks at after a 26-21 loss against Jacksonville Jaguars at Levi’s Stadium on September 28, 2025 in Santa Clara, California. (Brooke Sutton/Getty Images)
The 49er’s head coach Kyle Shanahan will have to lean on Star, running back Christian McCaffrey and Jones’s accuracy to prevent Rams from pulling away.



