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Buffalo Bills and Philadelphia Eagles are on top of the NFL throughout the first four weeks of the 2025 season and defeating each team that has been on their schedule so far.
In week 5, both teams can have their biggest test yet.
The bills host New England Patriots in a division -rivaling game that could affect future playoff poding if both Josh Allen and Drake Maye have strong seasons. Their matchup will put exclamation marks on an interesting Sunday.
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Eagles take their Super Bowl title defense tour back to Lincoln Financial Field to take on the Denver Broncos. Denver comes into the game with a fantastic defense that completely strangled Jake Browning and Cincinnati Bengals. Stopping tush -push is possibly one of the goals of broncos, but Eagles proved last week that they have some tricks up their sleeve to keep the defense on their toes.
Four teams have Byes this week, including Atlanta Falcons, Chicago Bears, Green Bay Packers and Pittsburgh Steelers. In addition, the Minnesota Vikings will be the first NFL team to play back-to-back international games with their matchup against Cleveland Browns in London.
Read below to see the rest of the schedule.
Thursday 2nd October 2025
San Francisco 49ers tight end Jake Tonges (88) is congratulated by teammates after scoring against Jacksonville Jaguars in the second half of a NFL football match in Santa Clara, California, Sunday 28 September 2025. (AP Photo/Godofredo A. Vásquez)
- San Francisco 49ers @ Los Angeles Rams (20:15 ET)
Sunday 5th October 2025
- Minnesota Vikings @ Cleveland Browns (9:30 am one)
- Las Vegas Raiders @ Indianapolis Colts (13:00 ET)
- New York Giants @ New Orleans Saints (13:00 ET)
- Dallas Cowboys @ New York Jets (13:00 ET)
- Denver Broncos @ Philadelphia Eagles (13:00 ET)
Vikings, Browns are facing in London in Rookie -quarterback Dillon Gabriel’s first start
Buffalo Bills Quarterback Josh Allen (17) is encrypted against New Orleans Saints in the first half of a NFL football match, Sunday 28 September 2025, in Orchard Park, New York. (AP Photo/Sue Ogrocki)
- Miami Dolphins @ Carolina Panthers (13:00 ET)
- Houston Texans @ Baltimore Ravens (13:00 ET)
- Tennessee Titans @ Arizona Cardinals (16:05 ET)
- Tampa Bay Buccaneers @ Seattle Seahawks (16:05 ET)
- Detroit Lions @ Cincinnati Bengals (16:25 ET)
- Washington Commanders @ Los Angeles Chargers (16:25 ET)
- New England Patriots @ Buffalo Bills (20:20 one)
Monday 6th October 2025
Kansas City Chiefs Quarterback Patrick Mahomes calls the line with review during the first half of an NFL football match against Baltimore Ravens Sunday 28 September 2025 in Kansas City, Missouri. (AP Photo/Charlie Riedel)
- Kansas City Chiefs @ Jacksonville Jaguars (20:15 ET)
