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With the 2026 NFL schedule now officially released, sportsbooks wasted no time in writing Week 1 opening lines.
Headlining a Super Bowl rematch on Wednesday night between the Seahawks and Patriots, as well as the NFL’s first-ever game in Australia between the Rams and 49ers, opening week is absolutely packed.
And while kickoff is still months away, it’s never too early to take an early look at Week 1 odds after the program release.
Here are the lines for each Week 1 matchup on the DraftKings Sportsbook starting May 15.
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WEDNESDAY SEP 9
Patriots @ Seahawks
Spread: Seahawks -3.5
Moneyline: Seahawks -205, Patriots +170
O/U: 44.5
THURSDAY 10 SEP
49ers @ Rams (Australia)
Spread: Aries -2.5
Moneyline: Rams -155, 49ers +130
O/U: 48.5
SUNDAY 13 September
Holy @ lions
Spread: Lions -7
Moneyline: Lions -325, Saints +260
O/U: 48.5
Bears @ Panthers
Spread: Bears -2.5
Moneyline: Bears -135, Panthers +114
O/U: 44.5
Ravens @ Colts
Distribution: Raven -3.5
Moneyline: Ravens -185, Colts +154
O/U: 49.5
Bills @ Texans
Spread: Bills -1.5
Moneyline: Bills -112, Texans -108
O/U: 45.5
Falcons @ Steelers
Spread: Steelers -3
Moneyline: Steelers -175, Falcons +145
O/U: 42.5
Buccaneers @ Bengals
Spread: Bengals -3.5
Moneyline: Bengals -198, Buccaneers +164
O/U: 50.5
Browns @ Jaguars
Spread: Jaguars -7
Moneyline: Jaguars -285, Browns +230
O/U: 40.5
Jets @ Titans
Spread: Titans -3
Moneyline: Titans -170, Jets +142
O/U: 39.5
Commanders @ Eagles
Spread: Eagles -5.5
Moneyline: Eagles -238, Commanders +195
O/U: 46.5
Packers @ Vikings
Spread: Packers -1.5
Moneyline: Packers -125, Vikings +105
O/U: 44.5
Cardinals @ Chargers
Spread: Chargers -11.5
Moneyline: Chargers -625, Cardinals +455
O/U: 45.5
Dolphins @ Raiders
Spread: Raiders -3
Moneyline: Raiders -180, Dolphins +150
O/U: 41.5
Cowboys @ Giants
Spread: Cowboys -2.5
Moneyline: Cowboys -130, Giants +110
O/U: 48.5
MONDAY SEP 14
Broncos @ Chiefs
Spread: Chiefs -2.5
Moneyline: Chiefs -155, Broncos +130
O/U: 42.5
